Cardiac preconditioning with 4-h, 17°C ischemia reduces [Ca ]i load and damage in part via KATP channel opening
نویسندگان
چکیده
QUN CHEN,1,5 AMADOU K. S. CAMARA,1 JIANZHONG AN,1 MATTHIAS L. RIESS,1,2 ENIS NOVALIJA,1,2 AND DAVID F. STOWE1,2,3,4 Anesthesiology Research Laboratories, Departments of 1Anesthesiology and 2Physiology, and 3Cardiovascular Research Center, The Medical College of Wisconsin, Milwaukee, 53226; 4Research Service, Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295; and 5Xuzhou Medical College, Xuzhou, People’s Republic of China 221002
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Wang, Lianguo, Gennady Cherednichenko, Lisa Hernandez, Jessica Halow, S. Albert Camacho, Vincent Figueredo, and Saul Schaefer. Preconditioning limits mitochondrial Ca21 during ischemia in rat hearts: role of KATP channels. Am J Physiol Heart Circ Physiol 280: H2321–H2328, 2001.—Prolonged myocardial ischemia results in an increase in intracellular calcium concentration ([Ca]i), which is thought ...
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Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia. Some K(+) currents are up-regulated in AC3-I hearts, but it is unknown if CaMKII inhibition increases the ATP sensitive K(+) current (I(KATP)) that underlies ischemic preconditioning (IP) and confers resistance to ischemia. We hy...
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BACKGROUND Brief sevoflurane exposure and washout (sevoflurane preconditioning [SPC]) before 30-min global ischemia at 37 degrees C is known to improve cardiac function, decrease cytosolic [Ca(2+)] loading, and reduce infarct size on reperfusion. It is not known if anesthetic preconditioning (APC) applies as well to hypothermic ischemia and reperfusion and if K(ATP) channels are involved. The a...
متن کاملEarly opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection.
ATP-sensitive potassium (KATP) channels are abundantly expressed in the myocardium. Although a definitive role for the channel remains elusive they have been implicated in the phenomenon of cardioprotection, but the precise mechanism is unclear. We set out to test the hypothesis that the channel protects by opening early during ischemia to shorten action potential duration and reduce electrical...
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